中线癌(nuclear protein in testis carcinoma),又称NUT癌,是一种罕见的高度侵袭性恶性肿瘤,最常见于中线器官和肺.NUT癌的特征性遗传学改变是NUT癌家族成员1(NUT midline carcinoma family member 1,NUTM1)基因重排.本文将对其最常见的融合形式溴结构域蛋白4(bromodomaincontaining protein 4,BRD4)-NUTM1融合基因的致病机制以及靶向药物研发的进展进行综述.
Abstract
NUT carcinoma(nuclear protein in testis carcinoma)is a rare and highly invasive malignant tumor,which is most common in midline organs and lungs.The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family member 1(NUTM1)gene.In this article,we will review the pathogenic mechanism of its most common fusion form,bromodomaincontaining protein 4(BRD4)-NUTM1 fusion gene,and the progress in the research and development of targeting drugs.
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