Role of Mitochondria in Ferroptosis and Its Relationship to Tumors
Ferroptosis is a recently discovered form of cell death that is distinct from apoptosis,characterized pri-marily by the accumulation of intracellular iron and increased levels of lipid peroxidation.Resistance of tumor cells to ferrop-tosis can promote tumorigenesis and tumor progression.Various compounds can influence tumor development by triggering ferroptosis.Ferroptosis involves complex regulatory mechanisms,with mitochondria serving as both an iron storage and meta-bolic center,playing a crucial regulatory role in ferroptosis.This review discusses ferroptosis and its three stages and the role of ferroptosis in tumorigenesis,progression,and treatment,as well as the regulatory mechanisms of mitochondria in ferroptosis.
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