Network Meta analysis on evaluation of clinical treatment of postpartum hemorrhage in Chinese population
Objective To systematically evaluate the safety and efficacy of current clinical measures for postpartum hemorrhage,assess the relative optimal treatment.Methods The relevant clinical control studies of treatment of postpartum hemorrhage were collected by searching PubMed,CNKI,VIP,and Wanfang database,the retrieval time was from building database to 1st October 2016.Literature Collection and data extraction were carried out by two reviewers independently,statistical analysis was performed by using Stata14.0 software.Results Finally,42 clinical controlled studies were included,and there were 3 768 patients with postpartum hemorrhage and 14 clinical treatments for postpartum hemorrhage.The successful rate of hemostasis was used as the evaluation index of clinical efficacy,the top 5 treatments were intrauterine ribbon gauze packing combined with hemabate,Bakri balloon tamponade combined with uterine artery ligation,B-Lynch suture combined with intrauterine balloon compression,oxytocin combined with carboprost methylate suppositories,oxytocin combined with hemabate and lower uterine segment continuous suture.The incidence rate of adverse events was used as a safety evaluation index,and the top 5 treatments were oxytocin combined with hemabate and lower uterine segment continuous suture,hemabate,oxytocin combined with carboprost methylate suppositories,Bakri balloon tamponade combined with uterine artery ligation,B-Lynch suture combined with intrauterine balloon compression.Conclusion The hemostatic efficiency of combination of various hemostatic measures is higher than that of single measure.Among the grading evaluation of curative effect,intrauterine ribbon gauze packing combined with hemabate may be the best measure.
Postpartum hemorrhageEfficacy evaluationSafety evaluationNetwork Meta analysis
NETL
NSTL
万方数据
维普
