胰腺衍生因子 成纤维细胞生长因子19及胎盘生长因子在妊娠期糖尿病中的表达及意义
Expression and significance of PANDER,FGF19 and PLGF in gestational diabetes mellitus
张维强 1郝阳 2李思雨3
作者信息
- 1. 天津市第一中心医院检验科,天津 300190
- 2. 天津市第一中心医院中医科
- 3. 天津中医药大学
- 折叠
摘要
目的 分析胰腺衍生因子(PANDER)、成纤维细胞生长因子19(FGF19)及胎盘生长因子(PLGF)在妊娠期糖尿病中的表达及意义.方法 选取2018年7月-2021年7月天津市第一中心医院收治的100例妊娠期糖尿病患者为观察组,另选取同期于院内进行体检的健康孕妇80例为对照组.检测两组PANDER、FGF19及PLGF表达,分析PANDER、FGF19及PLGF在妊娠期糖尿病中的表达及意义.结果 与对照组相比,观察组PANDER水平较高,FGF19、PLGF水平较低(t=49.640、13.620、44.730,均P＜0.05).与妊娠良好患者相比,妊娠不良患者PANDER水平较高,FGF19、PLGF水平较低(t=12.250、5.892、10.910,均P＜0.05).logistic回归显示PANDER、FGF19及PLGF为影响妊娠期糖尿病妊娠不良的危险因素.ROC曲线显示,3项联合对妊娠期糖尿病妊娠不良的预测价值高于PANDER、FGF19及PLGF单项检测(P＜0.05).结论 妊娠期糖尿病患者PANDER水平较高,FGF19、PLGF水平较低,且PANDER、FGF19及PLGF为娠期糖尿病妊娠不良的独立危险因素,联合检测对妊娠不良的预测价值较高.
Abstract
Objective To analyze the expression and significance of pancreatic derived factor(PANDER),fibroblast growth factor 19(FGF19)and placental growth factor(PLGF)in gestational diabetes mellitus.Methods A total of 100 patients with gestational diabetes admitted to our hospital from July 2018 to July 2021 were selected as the research group,and 80 healthy pregnant women undergoing physi-cal examination in the same period were selected as the control group.The expressions of PANDER,FGF19 and PLGF in the two groups were detected,and the expression and significance of PANDER,FGF19 and PLGF in gestational diabetes mellitus were analyzed.Results Compared with the control group,the levels of PANDER in the study group were higher,and the levels of FGF19 and PLGF were lower(t=49.640,13.620,44.730,all P＜0.05).Compared with patients with good pregnancy,patients with poor pregnancy had higher lev-els of PANDER and lower levels of FGF19 and PLGF(t=12.250,5.892,10.910,all P＜0.05).Logistic regression showed that PAN-DER,FGF19 and PLGF were risk factors affecting adverse pregnancy during gestational diabetes.ROC curve showed that the predictive val-ue of the combination of the three items for poor pregnancy of gestational diabetes mellitus was higher than that of PANDER,FGF19 and PL-GF(P＜0.05).Conclusion The level of PANDER in patients with gestational diabetes mellitus was higher,and the levels of FGF19 and PLGF were lower.PANDER,FGF19 and PLGF were independent risk factors for poor pregnancy in patients with gestational diabetes melli-tus.The combined detection had a higher predictive value for poor pregnancy.
关键词
妊娠期糖尿病/胰腺衍生因子/成纤维细胞生长因子19/胎盘生长因子Key words
Gestational diabetes mellitus/Pancreatic derived factor/Fibroblast growth factor 19/Placental growth factor引用本文复制引用
出版年
2025
NETL
NSTL
万方数据