Efficacy of different dosage forms of leuprorelin in central precocious puberty girls
Objective To investigate the therapeutic effect of 3-month and 1-month depot leuprorelin on girls with central precocious puberty.Methods Sixty girls with central precocious puberty(CPP)were randomly divided into two groups:3M group(30 cases):ac-cepted 3-month depot leuprorelin(11.25 mg)every 12 weeks,and 1M group(30 cases):received 1-month depot leuprorelin(3.75 mg)every 4 weeks.After 1 year of follow-up,the changes of luteinizing hormone(LH),follicle-stimulating hormone(FSH),uterine and ovari-an volume,growth rate and bone age were compared between the two groups,and the related adverse reactions were recorded.Results Comparison of the two groups:①peak LH(IU/L):16.20±14.58 and 13.75±9.66 at initial diagnosis,2.02±0.81 and 1.74±0.63 at 12 months follow-up,respectively.②Peak FSH(IU/L):18.81±9.22 and 15.37±5.49 at initial diagnosis,and 4.17±1.23 and 3.58±1.12 at 12 months follow-up,respectively.③Bone age index(bone age/chronological age):1.20±0.09 and 1.19±0.08 at initial diagnosis,1.16±0.07 and 1.15±0.07 at 12 months follow-up,respectively.④Ovarian volume(ml):3.60±1.24 and 3.20±1.34 at initial diagnosis,and 2.03±0.65 and 2.07±0.69 at 12 months follow-up,respectively.There were no significant differences between the all above two groups(all P＞0.05).It was suggested that the 3-month depot leuprorelin could well inhibit the level of sex hormones,control gonadal develop-ment,and control the progression of bone age,and there was no significant difference in efficacy from the 1-month depot leuprore-lin.Conclusion 3-month depot leuprorelin had the same inhibitory effect as 1-month depot on CPP girls,which is worth generalizing.
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