Objective To explore the correlation between the efficacy of intravenous immunoglobulin(IVIG)in children with primary immune thrombocytopenia(ITP)and the level of T lymphocyte subset changes.Methods A total of 80 ITP pediatric patients treated in Jin-hua People's Hospital from January 2020 to June 2023 were selected and randomly assigned into two groups:the observation group(n=40)and the control group(n=40),utilizing a random number table for the division.The observation group was given IVIG treatment,and the control group was given prednisone treatment.The efficacy of the two groups was compared,the platelet count and T lymphocyte subset chan-ges of the two groups were compared,and the correlation between the platelet count and T lymphocyte subset changes of the observation group was explored.Results There was a marked increase in the total efficacy rate in the observation group(92.50％)compared to that in the control group(75.00％),and this difference was statistically significant(P＜0.05).Compared with before treatment,the platelet count in both groups has improved,and the platelet count of the observation group improved significantly after treatment compared with the control group(P＜0.05).Compared with before treatment,The T lymphocyte subsets CD3+,CD4+,CD8+,CD4+/CD8+in both groups has improved,and the T lymphocyte subsets of the observation group improved significantly after treatment compared with the control group(P＜0.05).The platelet count of the observation group was positively correlated with CD3+,CD4+,CD4+/CD8+(r=0.674,0.722,0.691,P＜0.05),and negatively correlated with CD8+(r=-0.647,P＜0.05).Conclusion Peripheral blood T lymphocyte subset changes are closely related to the efficacy of IVIG in children with primary ITP,and the balance of T lymphocyte subset ratio is helpful to in-crease platelet count and improve therapeutic effect.
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