Peripheral blood T lymphocyte subset changes and the correlation between the efficacy of IVIG in children with primary immune thrombocytopenia
Objective To explore the correlation between the efficacy of intravenous immunoglobulin(IVIG)in children with primary immune thrombocytopenia(ITP)and the level of T lymphocyte subset changes.Methods A total of 80 ITP pediatric patients treated in Jin-hua People's Hospital from January 2020 to June 2023 were selected and randomly assigned into two groups:the observation group(n=40)and the control group(n=40),utilizing a random number table for the division.The observation group was given IVIG treatment,and the control group was given prednisone treatment.The efficacy of the two groups was compared,the platelet count and T lymphocyte subset chan-ges of the two groups were compared,and the correlation between the platelet count and T lymphocyte subset changes of the observation group was explored.Results There was a marked increase in the total efficacy rate in the observation group(92.50％)compared to that in the control group(75.00％),and this difference was statistically significant(P＜0.05).Compared with before treatment,the platelet count in both groups has improved,and the platelet count of the observation group improved significantly after treatment compared with the control group(P＜0.05).Compared with before treatment,The T lymphocyte subsets CD3+,CD4+,CD8+,CD4+/CD8+in both groups has improved,and the T lymphocyte subsets of the observation group improved significantly after treatment compared with the control group(P＜0.05).The platelet count of the observation group was positively correlated with CD3+,CD4+,CD4+/CD8+(r=0.674,0.722,0.691,P＜0.05),and negatively correlated with CD8+(r=-0.647,P＜0.05).Conclusion Peripheral blood T lymphocyte subset changes are closely related to the efficacy of IVIG in children with primary ITP,and the balance of T lymphocyte subset ratio is helpful to in-crease platelet count and improve therapeutic effect.
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