Clinical studies of multichannel amplitude-integrated electroencephalography in the assessment of brain injury in preterm infants
Objective To investigate the clinical significance of multichannel amplituid-integrated electroencephalography(aEEG)in evaluating brain injury in premature infants(BIPI).Methods A retrospective study was conducted on premature infants who completed aEEG examinations in the neonatal intensive care unit of Nanjing Maternity Hospital Affiliated to Nanjing Medical University from September 2019 to October 2022.According to brain damage diagnostic criteria,the preterm infants were divided into brain injury group and non-brain injury group.General data,postnatal complications,general conditions and critical disease of preterm infants during aEEG examination were coliected.Univariate and logistic regression models were used to analyze the related factors affecting BIPI.The aEEG scoring system was used to evaluate the brain development of preterm infants.The preterm infants were divided into normal aEEG group and abnormal aEEG group ac-cording to the comparison of the estimated gestational age with the corrected gestational age and combined with multi-channel original electro-encephalogram.The distribution of influencing factors of BIPI in normal aEEG group and abnormal aEEG group was analyzed.Neonatal criti-cal illness score(NCIS)was used in aEEG examination.The continuity,periodicity,amplitude,bandwidth,total and corrected total of aEEG parameters were analyzed and compared before and after aEEG examination.Results A total of 175 preterm infants were included,in-cluding 92 in the brain injury group and 83 in the non-brain injury group.Univariate and multivariate analysis indicated that aEEG,corrected gestational age,postnatal shock meningitis and hypoxic-ischemic encepha-lopathy were independent risk factors for brain injury in preterm infants(P＜0.05).According to the aEEG scoring system combined with multichannel primitive electroencephalogram,81 cases of normal aEEG group and 94 cases of abnormal aEEG group.There were significant differences in the distribution of matemal pregnancy-induced hy-pertension,post-natal shock,hypoxic-ischemic encephalopathy,age at examination,corrected gestational age and critical state between the two groups(P＜0.05).The comparison of 22 aEEG reexamination cases showed that there were statistically significant differences in conti-nuity,periodicity,lower boundary amplitude,bandwidth-level total score and correction total score of NCIS and aEEG(P＜0.05).Con-clusion Corrected Gestational age,postnatal shock and hypoxic-ischemic encephalopathy are not only risk factors for BIPI,but also influ-encing factors for abnormal aEEG.Multichannel aEEG can be helpful to evaluate BIPI.
NETL
NSTL
万方数据
