空气中依托咪酯和芬太尼的采集和检测
Collection and detection of airborne etomidate and fentanyl
刘昕 1杨发震 2孟东方 2常帅 3刘笑岚 1刘美1
作者信息
- 1. 云南警官学院,云南 昆明 650223;毒品分析及禁毒技术公安部重点实验室,云南 昆明 650223
- 2. 毒品分析及禁毒技术公安部重点实验室,云南 昆明 650223
- 3. 云南警官学院,云南 昆明 650223
- 折叠
摘要
目的 探究并初步建立空气中依托咪酯和芬太尼的采样、预处理和检测方法.通过探究空气中毒品成分的来源特征标记物,初步阐明空气依托咪酯和中芬太尼的来源特征.方法 通过鼓泡吸收和截停滤膜采集空气颗粒物(PM)采集室内燃吸烟气中的依托咪酯和芬太尼;通过甲醇萃取PM中的依托咪酯和芬太尼;通过GC-MS定性检测吸收液和萃取液中的依托咪酯、芬太尼及其燃吸来源标记物(尼古丁);通过UPLC-MS/MS对吸收液和PM萃取液中依托咪酯和芬太尼进行定量,推算了室内PM态依托咪酯和芬太尼的含量.结果 室内燃吸烟气中PM态依托咪酯含量约为 750.70 ng/m3,芬太尼含量约为 399.07 ng/m3.结论 实验条件下,PM采集法的采样效率高于烟气吸收法.尼古丁可作为PM中依托咪酯和芬太尼的燃吸来源标记物.实验为空气PM中毒品来源特征分析提供了新实践案例.
Abstract
Objective To explore and establish preliminary methods for sampling,pretreatment,and detection of airborne etomidate and fentanyl.By finding and selecting source-marking molecules of illicit drugs,preliminarily elucidated the source characteristics of airborne etomidate and fentanyl.Methods Etomidate and fentanyl-containing flue gas have been produced via simulated smoking,while the flue gas has been collected through bubbling absorption or filter membrane;The collected PM have been extracted by ethanol for gas chromatography-mass spectrometry(GC-MS)analysis of etomidate,fentanyl and marking molecules(nicotine).Additionally,ultra-high performance liquid chromatography triple quadrupole mass spectrometry(UPLC-MS/MS)have been implemented to quantify concentration of etomidate and fentanyl in PM extraction solution for estimating content of airborne PM-containing etomidate and fentanyl.Results The estimated content of indoor PM-containing etomidate generated from smoking is 750.70 ng/m3,and the estimated content of indoor PM-containing fentanyl is 399.07 ng/m3.Conclusion Under the experimental conditions,the sampling efficiency of PM filtration is higher than that of flue-gas blubbing absorption.Nicotine can serve as a marker for the smoking or thermal-inhaling sources of PM-containing etomidate and fentanyl.The present research provides a new practical case for analyzing the source characteristics of airborne PM-containing illicit drugs.
关键词
空气/依托咪酯/芬太尼/采集/标记物Key words
Air/Etomidate/Fentanyl/Collection/Marking molecules引用本文复制引用
基金项目
公安部科技计划项目—科技强警基础工作专项(2023JC37)
云南省科技计划项目基础研究专项—青年项目(202101AU070020)
云南省教育厅科学研究基金项目(2021J0697)
出版年
2024
NETL
NSTL
万方数据