首页|常染色体InDel标记的法医物证应用与研究进展

常染色体InDel标记的法医物证应用与研究进展

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插入/缺失多态性(Insertion/deletion,InDel)标记是基因组中一类广泛分布的长度多态性遗传标记,兼具STR和SNP的特点.InDel标记可应用于降解生物检材的个体识别、复杂亲缘关系鉴定等工作,可通过个体族源推断以缩小侦查范围,在法医物证检验分析中具有重要的实践价值.随着Multi-InDel和多等位基因InDel标记研究工作的广泛开展,InDel标记的鉴定效能不断提升,其法医应用场景也不断扩大.本文就InDel标记在法医物证检验中的应用与发展进行回顾总结,探讨未来InDel标记研究的发展方向.
Application and research progress of autosomal InDel markers in forensic genetics
Insertion/deletion polymorphism(InDel)markers are a class of length polymorphic genetic markers widely distributed in genomes,which have the characteristics of both STR and SNP.InDel markers can be applied to the work like individual identification of degraded materials and the identification of complex relationship.It can narrow the scope of investigation by ancestral inference,which have important practical value in forensic genetics inspection and analysis.With the development of research on Multi-InDel and Multi-allelic InDel markers,the identification efficiency of InDel markers continues to improve,and their forensic application scenarios are also expanded.This review summarized the application and development of InDel markers in forensic genetics,and explored the development in the future.

Forensic geneticsInDelDegraded samplesInference of ancestryMulti-InDelMulti-allelic InDel

李智敏、姚以宁、周芷菡、季琪琪、谢建辉

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复旦大学基础医学院法医学系,上海 200032

法医物证学 插入/缺失多态性 降解检材 族源推断 Multi-InDel 多等位基因InDel

2024

中国法医学杂志
中国法医学会

中国法医学杂志

CSTPCD
影响因子:0.352
ISSN:1001-5728
年,卷(期):2024.39(6)