Predictive Value of Combined Detection of Serum CTRP6 and FSTL1 in Coronary Artery Restenosis in Patients with Coronary Heart Disease
Objective To explore the predictive value of combined detection of serum C1q/tumor necrosis factor-related protein 6(CTRP6)and follicular statin-like protein-1(FSTL1)for coronary artery in-stent restenosis(ISR)in patients with coronary artery disease after percutaneous coronary intervention(PCI).Methods A total of 128 patients with coronary heart disease admitted to our hospital from January 2020 to July 2021 were regarded as the study subjects.The clinical data of patients were collected,and the serum levels of CTRP6 and FSTL1 were detected by enzyme linked immunosorbent assay(ELISA).The patients were followed up for 12 months after PCI.According to the occurrence of ISR,the patients were divided into ISR group(n=32)and NISR group(n=96);the predictive value of serum CTRP6 and FSTL1 for the occurrence of ISR in patients with coronary heart disease after PCI was analyzed by receiver operating characteristic(ROC)curve;and Logistic regression was applied to analyze the influencing factors of ISR in patients with coronary heart disease after PCI.Results The length of coronary artery lesion in ISR group was longer than that in NISR group,and the number of stents implanted was more than that in NISR group(all P＜0.05).The level of serum CTRP6 in ISR group was obviously lower than that in NISR group,and the level of FSTL1 was obviously higher than that in NISR group(all P＜0.05).With the aggravation of ISR lesion,the proportions of patients with low expression of CTRP6 and high expression of FSTL1 in serum increased gradually,the lesion length of patients with low expression of serum CTRP6 and high expression of FSTL1 was obviously longer than that of patients with high expression of serum CTRP6 and low expression of FSTL1(all P＜0.05).The area under the curve(AUC)of serum CTRP6,FSTL1 and their combination in predicting the occurrence of ISR in patients with coronary heart disease after PCI was 0.824,0.808 and 0.904,respectively,the predictive efficacy of the combination of CTRP6 and FSTL1 was obviously better than that of their independent prediction(all P＜0.05).Logistic analysis showed that serum CTRP6 and FSTL1 were the influencing factors of ISR in patients with coronary heart disease after PCI(all P＜0.05).Conclusion The level of serum CTRP6 is down regulated and the level of serum FSTL1 is up regulated in patients with coronary heart disease with ISR after PCI,the combination of the two has high predictive value for the occurrence of ISR after PCI,which can provide a reference for evaluating the prognosis of patients with coronary heart disease.
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