Research Progress of the Relationship between β3-adrenergic Receptors and Coronary Heart Disease
β-adrenergic receptors(β-ARs)play pivotal roles in the pathogenesis of coronary heart disease(CHD)and include three subtypes:β1,β2,and β3,which are widely expressed in the body and regulate many physiological processes.Studies found β3-AR can mediate brown adipocyte thermogenesis and energy consumption,and the mutation of the β3-AR gene is closely related to dyslipidemia,insulin resistance,diabetes,hypertension,and other CHD factors.Moreover,the activation of β3-AR exerts a cardioprotective impact following myocardial infarction.This review aims to summarize the molecular structure,the expression in the heart,and the physiological function of β3-AR.Furthermore,we discuss the potential role of β3-AR in the pathogenesis of CHD and predict the potential of β3-AR as a risk predictor or novel therapeutic target for CHD.
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