Pathophysiology of WFDC2 in Ventricular Remodeling after Myocardial Infarction
Ventricular remodeling after myocardial infarction can lead to the occurrence of heart failure,which is one of the key factors affecting the quality of life and life expectancy of patients after myocardial infarction.Myocardial fibrosis plays a crucial role in the pathogenesis of heart failure after myocardial infarction,and WAP four-disulfide core domain 2(WFDC2),a secreted protein expressed in activated fibroblasts,exacerbates tissue fibrosis.This review focuses on the structure and function of WFDC2,highlighting the possible role of WFDC2 in ventricular remodeling after myocardial infarction.
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