Relationship between Serum β-catenin and E-cadherin Levels and Coronary Artery Stenosis in Elderly Patients with Coronary Heart Disease
Objective To explore the relationship between serum levels of β-catenin and E-cadherin and coronary artery stenosis in elderly patients with coronary heart disease.Methods A total of 206 elderly patients with coronary heart disease admitted to our hospital from July 2021 to July 2023 were selected as the research objects(observation group).According to the degree of coronary artery stenosis,they were divided into mild stenosis group(Gensini score ≤24,n=122)and moderate to severe stenosis group(Gensini score＞24,n=84).In addition,250 healthy people who underwent physical examination during the same period were selected as the control group.The levels of serum β-catenin and E-cadherin were detected by enzyme-linked immunosorbent assay.Multivariate Logistic stepwise regression analysis was used to explore the influencing factors of the degree of coronary artery stenosis in elderly patients with coronary heart disease.Results The serum β-catenin level in observation group was higher than that in control group,and the serum E-cadherin level was lower than that in control group(all P＜0.05).The serum β-catenin level in moderate and severe stenosis group was higher than that in mild stenosis group,and the serum E-cadherin level was lower than that in mild stenosis group(all P＜0.05).Age,smoking rate,diabetes history rate,white blood cell count and LDL-C in moderate to severe stenosis group were higher than those in mild stenosis group,and HDL-C was lower than those in mild stenosis group(all P＜0.05).History of diabetes(OR=2.333,95％CI:1.558-3.493),β-catenin≥1.22 pg/mL(OR=3.133,95％C1:2.012-4.879),E-cadherin ≤3.61 ng/mL(OR=2.625,95％CI:1.702～4.048)were risk factors for coronary artery stenosis degree in elderly patients with coronary heart disease,and HDL-C(OR=0.467,95％CI:0.320-0.680)was a protective factor for the degree of coronary artery stenosis in elderly patients with coronary heart disease(all P＜0.05).Conclusion The increase of serum β-catenin level and the decrease of E-cadherin level in elderly patients with coronary heart disease are closely related to the degree of coronary artery stenosis.Increased serum β-catenin and decreased serum E-cadherin are risk factors for coronary artery stenosis degree in elderly patients with coronary heart disease.
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