Research Progress on the Role of Yin-Yang 1 in Cardiac Development and Heart Disease
Cardiac development is regulated by the transcriptome of cardiac-specific genes encoded in a spatial/temporal precise manner in mammalians.Epigenetic factors play a critical role in regulating gene transcription in cardiomyocytes.Chromatin regulation,as an important epigenetic modification of eukaryotes,plays a crucial role in this process.Yin-Yang 1(YY1),a subunit of the chromatin remodeling complex IN080,acts as a transcription factor that interacts with specific proteins to selectively activate or repress gene transcription,thus playing a key role in numerous biological processes.Recent studies have proved that YY1 is significant in the regulation of cardiac development,cardiac functional integration,and pathological remodeling of the myocardium,and significant breakthroughs have been achieved.These findings provide a new theoretical and experimental support for the occurrence and development of heart disease and indicate that YY1 is expected to be a useful target for the treatment of human heart disease.This article aims to review the research progress of YY1 in regulating cardiac development and pathological remodeling.
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