Association of Total Cholesterol/High-Density Lipoprotein Cholesterol Ratio and Remnant Cholesterol with Coronary Artery Calcification
Objective To investigate the relationship and significance of the ratio of total cholesterol(TC)to high-density lipoprotein cholesterol(HDL-C)and remnant cholesterol(RC)with coronary artery calcium score(CACS).Methods In this cross-sectional study,coronary angiographic data were acquired using 64-row spiral CT in a community-based population of 2 868 individuals from the Hebei Jidong cohort.The total calcification score was determined by summing the individual lesion scores for each anatomical site:left main artery(LM),left anterior descending artery(LAD),left circumflex artery(LCX),right coronary artery(RCA),and aorta(AO).The amount of calcium present in the coronary arteries was scored according to the Agatston score,and participants were divided into two groups based on the absence(CACS=0)or presence(CACS＞0)of CAC,and lipid indices were calculated and compared between the two groups;they were further classified into four groups according to the severity of CAC(no,mild,moderate,or severe calcification),and the TC/HDL-C ratio as well as RC were analyzed association of both with the severity of CAC.Results After adjusting for confounders,elevated TC/HDL-C ratio and RC levels were significantly associated with elevated LAD,AO,and total CACS.Stratified analyses showed that the positive correlation between TC/HDL-C ratio and CAC was more significant in the LAD of women.Additionally,grouped by TC/HDL-C ratio quartiles,the risk of positive LAD,AO,and total CAC scores increased progressively with higher TC/HDL ratios,with the highest quartile group being 1.84,2.15,and 2.18 times higher than the lowest quartile group,respectively.TC/HDL-C ratio and RC levels were also positively correlated with CAC severity.The TC/HDL-C ratio and RC levels were also positively correlated with CAC severity,which progressively worsened with increasing TC/HDL-C ratio and RC levels.Conclusion Elevated TC/HDL-C ratio as well as RC levels are associated with multisite CAC,and they may be independent risk factors for CAC.
NETL
NSTL
万方数据
