Expression of UFM1 and GDF15 in Peripheral Blood Mononuclear Cells of Coronary Heart Disease Patients
Objective To investigate the expression of growth differentiation factor 15(GDF15)and ubiquitin-fold modifier 1(UFM1)in peripheral blood mononuclear cells(PBMCs)in patients with coronary heart disease(CHD)and the correlation between the expressions of them.Methods A total of 181 patients who visited the Department of Cardiology at our hospital from December 2020 to May 2021 and underwent coronary angiography were collected.Among them,16 patients with coronary heart disease were excluded(NC group)and 165 patients with confirmed coronary heart disease(CHD group).Peripheral blood was collected and total RNA was extracted from PBMC,and the expression level of GDF15 and UFM1 in PBMC was compared.Results The relative expression levels of GDF15 in the NC and CHD groups were 0.694(1.667)and 1.275(2.082),while the relative expression of UFM1 in NC and CHD groups were 1.088(1.618)and 1.675(1.206),respectively.Compared with the NC group,the expression levels of GDF15 and UFM1 in the CHD group were both significantly increased(P=0.042 3,P=0.003 4).The expression of UFM1 was positively correlated with GDF15 in PBMCs(r=0.4435,P＜0.0001).Multivariate logistic regression showed that age,hyperlipidemia,and UFM1 expression levels were risk factors for CHD.High UFM1 level increased the risk of CHD(OR=4.170,P=0.009).Conclusion The increased level of UFM1 in PBMC is closely related to CHD,and may have certain guiding value for the clinical diagnosis and treatment of CHD.
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