Research Progress on the Role and Mechanism of MicroRNA-133 in Cardiac Remodeling
Cardiac remodeling is a key pathological process in the development of cardiovascular diseases.According to the mechanisms that lead to cardiac dysfunction,cardiac remodeling can be divided into structural remodeling,electrical remodeling and energy metabolism remodeling.MicroRNAs(miRNAs)are highly conserved non-coding endogenous small RNAs that play a variety of regulatory roles in cells.A large number of studies have confirmed that miR-133 is one of the micrornas highly expressed in the heart and closely related to cardiac remodeling.By regulating the expression of target genes,miR-133 mediates the activation or inhibition of related signaling pathways,and participates in the proliferation,differentiation and cardiac electrophysiological processes of cardiomyocytes and myocardial fibroblasts.In this paper,three different pathologic processes of cardiac remodeling were taken as the breakthrough point to explore the key role and potential mechanism of miR-133,in order to provide new ideas for understanding the mechanism of cardiac remodeling and nucleic acid-based drug development.
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