Research Advances in p16INK4a and the Pathogenesis of Diabetic Cardiomyopathy
With the current aging society,as a common geriatric disease,the incidence of diabetes is increasing year by year,and the number of diabetic cardiomyopathy as one of the complications of diabetes is also increasing.Diabetic cardiomyopathy is not only an important cause of heart damage and the development of heart failure in diabetic patients,but also a specific myocardial injury in addition to secondary damage such as coronary artery disease.Previous studies have shown that the onset of diabetic cardiomyopathy is often caused by inflammatory aging,oxidative stress,mitochondrial damage,and abnormal glucolipid metabolism.Recent studies have shown that senescence factors,such as p16INK4a are closely associated with the development and progression of diabetic cardiomyopathy and exacerbate high-glucose-induced myocardial injury.In this paper,we will reveal the role of senescence factors within the development of diabetic cardiomyopathy and thus improve the understanding of diabetic cardiomyopathy and aging,then find ideas for studying the relationship between diabetic cardiomyopathy and senescence factors.
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