孟德尔随机化在心力衰竭病因探索中的应用
Advance in the Etiology of Heart Failure Based on Mendelian Randomization
商鲁翔 1孙华鑫 2汤宝鹏 2侯应龙1
作者信息
- 1. 山东第一医科大学第一附属医院(山东省千佛山医院)心血管病学,山东省医药卫生心律失常重点实验室,济南 250014
- 2. 新疆医科大学第一附属医院起搏电生理科,新疆心电生理与心脏重塑重点实验室,乌鲁木齐 830054
- 折叠
摘要
临床观察性研究显示多种危险因素及生物标志物与心力衰竭的发生密切相关.受限于观察性研究的局限性,无法判定这些因素与心力衰竭的因果关系.孟德尔随机化是以遗传变异作为工具变量的统计模型,近年来被广泛应用于因果关联研究.目前已有多项研究利用孟德尔随机化方法探索了不同危险因素和/或生物标志物与心力衰竭的因果关系,本文拟对基于孟德尔随机化的心力衰竭病因学研究进展进行综述.
Abstract
Clinical observational studies have shown that multiple risk factors and biomarkers are closely related to the occurrence of heart failure.Due to the limitations of observational studies,the causal relationship between these factors and heart failure cannot be determined.In recent years,Mendelian randomization(MR),using genetic variants as instrumental variables for exposure,has been widely used in causal association studies.Many studies have used MR to explore the causal relationship of different risk factors and/or biomarkers with heart failure.This article intends to review the progress of the etiology of heart failure based on MR analysis.
关键词
心力衰竭/孟德尔随机化/病因学/因果关系/流行病学研究Key words
Heart failure/Mendelian randomization/Etiology/Causal relationship/Epidemiological study引用本文复制引用
基金项目
国家重点研发计划(2016YFC0900905)
临床流行病学北京市重点实验室开放课题()
出版年
2024
NETL
NSTL
万方数据