Correlation between Glycosylated Hemoglobin Ale Level and the Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction and Diabetes Mellitus
Objective To investigate the effect of glycosylated hemoglobin Alc(HbA1c)level on the severity of coronary artery disease in patients with acute myocardial infarction(AMI)and diabetes(DM).Methods A study was conducted on 213 patients with AMI and DM who were admitted to Capital Medical University Daxing Teaching Hospital from January to December 2020.All patients underwent coronary angiography,and the severity of coronary lesions was evaluated using the SYNTAX score and divided into three groups:SYNTAX score 0-22 for mild lesions,SYNTAX score 23-32 for moderate lesions,and SYNTAX score greater than 32 for severe lesions.The HbA1c levels of enrolled patients were also measured.Logistic regression analysis was used to investigate the correlation between HbA1c levels and the severity of coronary artery disease.Results The average HbAlc level gradually increased in the three groups of patients,and there was a statistically significant difference(P<0.05)between the mild lesion group(6.9%±1.1%),the moderate lesion group(8.7%±1.4%),and the severe lesion group(10.1%±1.6%).In the subgroup analysis of acute ST segment elevation myocardial infarction group and non ST segment elevation myocardial infarction group,it was found that there was a statistically significant difference in HbAlc levels between mild and severe lesions(P<0.05).Simple linear regression analysis showed a correlation between HbA1c levels and SYNTAX scores(r=0.212,P<0.001).Further logistic regression analysis showed that HbAlc levels were an independent influencing factor for severe coronary artery disease in patients with AMI and DM(OR=3.630,95%CI:1.785-7.378,P<0.05).Conclusion HbAlc level is closely related to the severity of coronary artery disease and is an independent influencing factor for severe coronary artery disease in patients with AMI and DM.Effective blood glucose management may reduce the severity of coronary artery disease.