首页|硝苯地平控释片联合硫酸镁对妊娠高血压患者血管内皮功能及妊娠结局的影响

硝苯地平控释片联合硫酸镁对妊娠高血压患者血管内皮功能及妊娠结局的影响

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目的 探讨硝苯地平控释片联合硫酸镁对妊娠高血压患者血管内皮功能和妊娠结局的影响.方法 2021年3月1日至2023年3月31日,从西北妇女儿童医院收治的妊娠高血压孕妇中选择152例作为研究对象.根据随机数表法分为对照组和观察组,每组76例.观察组采用硝苯地平控释片与硫酸镁联合用药,对照组仅采用硫酸镁治疗.主要研究终点为临床疗效,次要终点包括血压水平(收缩压和舒张压)、血清一氧化氮(NO)和内皮素-1(ET-1)水平、不良反应和妊娠结局.结果 观察组和对照组总有效率分别为85.53%和69.74%(P=0.020).治疗后,两组血清NO水平明显升高,收缩压、舒张压及血清ET-1水平和ET-1/NO比值明显降低(P均<0.05);观察组NO高于对照组,收缩压、舒张压、血清ET-1水平和ET-1/NO比值低于对照组(P均<0.05).两组不良反应发生率分别为7.89%和6.58%(P>0.05),观察组妊娠并发症发病率更低(P<0.05).血清ET-1水平与收缩压、舒张压呈正相关,血清NO水平与收缩压呈负相关(P均<0.05).结论 硫酸镁与硝苯地平控释片联合用药可降低妊娠高血压患者血压,改善血管内皮功能障碍,调节血清ET-1和NO水平,降低并发症发生率,提高疗效.
Effect of Nifedipine Controlled Release Tablets Combined with Magnesium Sulfate on Vascular Endothelial Function and Pregnancy Outcome in Patients with Hypertensive Disorders of Pregnancy
Objective To investigate the effects of nifedipine controlled release tablets combined with magnesium sulfate on vascular endothelial function and pregnancy outcome in patients with hypertensive disorders of pregnancy(HDP).Methods From March 1,2021 to March 31,2023,152 HDP pregnant women who were admitted to our hospital were included as research objects.According to the method of random number table,they were randomly divided into control group and observation group,with 76 cases in each group.The observation group was treated with nifedipine controlled release tablets combined with magnesium sulfate,while the control group was treated with magnesium sulfate only.The primary endpoint was clinical efficacy.Secondary endpoints included blood pressure levels(systolic and diastolic pressure),serum nitric oxide(NO)and endothelin-1(ET-1)levels,adverse reactions,and pregnancy outcomes.Results The total effective rate of the observation group and the control group were 85.53%and 69.74%,respectively(P=0.020).After treatment,serum NO level was significantly increased in both groups,while systolic blood pressure,diastolic blood pressure,serum ET-1 level and ET-1/NO were significantly decreased(all P<0.05).NO level in observation group was higher than that in control group,while systolic blood pressure,diastolic blood pressure,serum ET-1 level and ET-1/NO were lower than those in control group(all P<0.05).The incidence of adverse reactions in the two groups was 7.89%and 6.58%,respectively(P>0.05).The incidence of pregnancy complications was lower in the observation group(P<0.05).In the overall analysis,ET-1 was positively correlated with the systolic and diastolic blood pressure,and NO was negatively correlated with the systolic blood pressure(all P<0.05).Conclusion Magnesium sulfate combined with nifedipine controlled release tablets can reduce blood pressure in HDP patients,improve vascular endothelial dysfunction,regulate serum ET-1 and NO levels,reduce the incidence of complications and improve curative effect.

Hypertensive disorders of pregnancyNifedipine controlled release tabletMagnesium sulfateVascular endothelial functionPregnancy outcome

郑静静、赵蓓、牛茜

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西北妇女儿童医院产科,西安 710061

妊娠高血压 硝苯地平控释片 硫酸镁 血管内皮功能 妊娠结局

陕西省卫生健康科研基金项目

2021D020

2024

中国分子心脏病学杂志
中国医学科学院,中国协和医学院

中国分子心脏病学杂志

CSTPCD
影响因子:0.426
ISSN:1671-6272
年,卷(期):2024.24(4)