Relationship between Serum UA and NRG-1 and All-cause Death in the Vulnerable Phase in Patients with Acute Heart Failure
Objective To investigate the relationship between serum uric acid(UA)and neuregulin-1(NRG-1)and all-cause death in the vulnerable phase in patients with acute heart failure(AHF).Methods A total of 92 patients with AHF admitted to the hospital from September 2020 to September 2021,and 46 patients with acute chest pain(control group)were included in this study.Serum UA and NGR-1 levels were compared between the two groups.According to the presence or absence of all-cause death in the vulnerable phase,patients with AHF were divided into all-cause death group and non-all-cause death group.Serum UA and NGR-1 were compared between the two groups.The predictive value of serum UA,NGR-1,and combination of the two for all-cause death was analyzed using the receiver operating characteristic(ROC)curve.The relationship between serum UA and NGR-1 and all-cause death was analyzed using Kaplan-Meier curve.COX proportional hazard model was used to analyze the relationship between serum UA and NRG-1 and all-cause death in the vulnerable phase in patients with AHF.Results Serum UA and NGR-1 levels in the AHF group[(0.41±0.13)μmol/L and(1.49±0.28)ng/mL]were higher than those in the control group[(0.12±0.03)μmol/L,(1.01±0.21)ng/mL](P＜0.05).Serum UA and NGR-1 levels in the all-cause death group[(0.49±0.11)μmol/L and(1.67±0.32)ng/mL]were higher than those in the non-all-cause death group[(0.40±0.13)μmol/L and(1.46±0.26)ng/mL](P＜0.05).ROC curve analysis found that the area under the curve(AUC)and specificity of UA combined with NGR-1 for predicting all-cause death in patients with AHF were higher than those of single prediction(Z=2.690,2.244,P＜0.05).Kaplan-Meier curve analysis found that the survival rates of patients with high UA level and high NGR-1 level(74.4％and 77.3％)were significantly lower than those with low UA level and low NGR-1 level(94.7％and 93.8％)(Log-rankx2=5.550,4.139,P＜0.05).Cox proportional hazard model analysis confirmed that serum UA and NGR-1 levels were influencing factors of all-cause death in the vulnerable phase in patients with AHF(P＜0.05).Conclusion Serum UA and NRG-1 are closely related to all-cause death in patients with AHF in vulnerable phase,which indicates that they can be used to predict all-cause death in patients with AHF.
Uric acidNeuregulin-1Acute heart failureVulnerable phase of heart failureAll-cause death
NETL
NSTL
万方数据
