Advances on the Roles of Mammalian Rapamycin Target Protein Signal Pathway and Pharmacotherapy in Pulmonary Hypertension
Pulmonary hypertension(PH)is a kind of progressive and fatal disease characterized by changes in the structure and function of pulmonary vessels and right heart failure caused by increased pulmonary artery pressure.Mammalian rapamycin target protein(mTOR)is a key node in regulating cell proliferation,metabolism and survival.It combines different subunits to form mTOR complex 1(mTORC1)and mTOR complex 2(mTORC2)respectively,which play vital roles in multiple pathological stages of PH and are closely associated with the occurrence and development of pulmonary vascular remodeling and right ventricular dysfunction.mTORC1 may be a promising therapeutic target for PH.In this review,we summarized the roles of mTOR signal pathway in PH and the latest research progress of targeted therapy of this signal pathway in PH.
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