Research Progress of Acute Kidney Injury in Patients Supported with Venous-arterial Extracorporeal Membrane Oxygenation
Venous-arterial extracorporeal membrane oxygenation(V-A ECMO)has been widely used in patients with severe cardiopulmonary failure,which can provide temporary life support and reduce patient mortality.However,during V-A ECMO,there are some complications,among which acute kidney injury(AKI)is more common.The patient's basic physiological state,management during V-A ECMO,and changes in biochemical indicators due to hemolysis and hypoperfusion are all associated with the development of acute kidney injury.Ischemic injury,inflammatory reaction,and hemolysis play indispensable roles in the damage of kidney function.Severe AKI is associated with a poor prognosis in patients,and renal replacement therapy is an effective treatment strategy.This article reviews the research progress on the risk factors,pathophysiological mechanism,treatment and prognosis of AKI in patients treated with V-A ECMO,in order to provide theoretical reference for early clinical recognition and intervention.
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