Research progress on sequential immunization strategies of COVID-19 vaccines:a review
The global pandemic of the coronavirus disease 2019(COVID-19)has had a serious impact on global life safety and economic development.Vaccination with the coronavirus disease vaccine(COVID-19 vaccine)is an important measure to prevent infection,reduce the incidence and severity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Currently,there are six different technological routes for COVID-19 vaccines worldwide,including protein subunit vaccines,nucleic acid vaccines(mRNA vaccines and DNA vaccines),viral vector vaccines,inactivated vaccines,virus-like particle vaccines,and attenuated vaccines.Sequential immunization strategy is a valid approach for solving vaccine shortages,responding to viral variants,and improving vaccine efficacy by administering COVID-19 vaccines of different technological routes at specific time intervals and doses.Many scholars at home and abroad have conducted research on the sequential immunization strategy of COVID-19 vaccines.This article provided an overview of the research on the sequential immunization strategy of COVID-19 vaccines at home and abroad in five aspects:COVID-19 inactivated vaccine and mRNA vaccine,COVID-19 inactivated vaccine and adenovirus vector vaccine,COVID-19 inactivated vaccine and protein subunit vaccine,COVID-19 adenovirus vector vaccine and mRNA vaccine,COVID-19 adenovirus vector vaccine and protein subunit vaccine,aiming to provide reference for the inoculation and formulation of immunization strategies for COVID-19 vaccines.
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