Antihypertensive regimen among primary hypertension inpatients,2015-2018:an analysis on medical records of three tertiary hospitals in Anshan city
Objective To examine antihypertensive regimens among primary hypertension inpatients during 2015-2018 in Anshan city of Liaoning province for evaluating rational medication of hypertensive patients.Methods Using stratified random sampling through hospital information systems,we extracted medical records of 3 600 primary hypertension patients hospitalized at three tertiary first-class hospitals during 2015-2018(300 records/per year/per hospital)in Anshan city.The clinical characteristics and antihypertensive regimens of the inpatients were statistically analyzed.Results Of all the inpatients,525(14.58％),1 032(28.67％),and 2043(56.75％)were diagnosed with hypertension of stage Ⅰ,Ⅱ,and Ⅲ,respectively.The proportions of the inpatients having concomitant diseases were 21.17％for left ventricular hypertrophy,8.36％for carotid atherosclerosis,14.28％for coronary heart disease,9.00％for heart failure,12.42％for ischemic stroke,7.47％for hemorrhagic stroke,and 6.31％for chronic kidney disease.Among all the inpatients during the hospitalizations,1 004(27.89％)had single antihypertensive medication and 2 596(72.11％)had combined antihypertensive medication.Among the monotherapy regimens,calciumion antagonists(CCB)was the most frequently used drug in 325(32.37％)of the inpatients,followed by angiotensin converting enzyme inhibitors(ACEI)in 210(20.92％)of the inpatients.Of the inpatients with the combined regimens,588(22.65％)had the medication of ACEI/angiotensin receptor blocker(ARB)plus CCB plus diuretic and 587(22.61％)had the medication of ACEI/ARB plus β-receptor blocker plus CCB.The antihypertensive regimens differed significantly by hypertension stage among the inpatients(x2=1 922.86,P＜0.001).Conclusion For the primary hypertensive patients hospitalized during 2015-2018 in Anshan city,more than a half had stage Ⅲ hypertension and left ventricular hypertrophy,coronary artery disease,and ischemic stroke were major concomitant diseases;CCB was a main monotherapy and ACEI/ARB plus CCB plus diuretic was a main combined antihypertensive regimen in the treatment of the inpatients during hospitalization.
hypertensioninpatientspharmacoepidemiologycharacterizationAnshan city
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