Association and predictive value of Non-HDL-C,ApoB,and LDL-C with metabolic syndrome among adult rural Uyghur residents:a cross-sectional survey in Xinjiang Uygur Autonomous Region
Objective To explore the association and predictive value of non-high-density lipoprotein cholesterol(Non-HDL-C),apolipoprotein B(ApoB)and low-density lipoprotein cholesterol(LDL-C)with metabolic syndrome(MS)in adult rural residents of Xinjiang Uygur Autonomous Region for facilitating early identification and prevention of MS in the residents.Methods The study enrolled 6 500 Uygur residents aged ≥ 18 years from 12 villages in the Kashgar region of Xinjiang Uygur Autonomous Region(Xinjiang)using a multistage random cluster sampling method.Face-to-face interviews were conducted during July-August 2017 using a self-designed questionnaire,along with physical examinations and laboratory tests.Unconditional multivariate logistic regression analysis and receiver operating characteristic(ROC)curve analysis were employed to assess the association between Non-HDL-C,ApoB,and LDL-C with MS,as well as to evaluate their predictive value for MS.Results The analysis finally included a total of 5 156 participants,among whom 885(17.2％)were identified as having MS.After adjusting for potential confounding factors including gender,age,education,smoking status,alcohol consumption,and body mass index,the results of multivariate unconditional logistic regression analysis revealed a significantly increased risk of MS among participants in the highest quartile ofNon-HDL-C levels(odds ratio[OR]=1.764;95％confidence interval[CI]:1.350-2.305).Similarly,participants in the third and highest quartiles of ApoB had a higher risk compared to those in the lowest quartile(OR=1.372;9 5％CI:1.048-1.798 and OR=1.645;95％CI:1.273-2.124 respectively).Additionally,individuals in the highest quartile of LDL-C had an elevated risk compared to those in the lowest quartile(OR=1.403;95％CI:1.080-1.823).The receiver operating characteristic(ROC)analysis results revealed that Non-HDL-C,ApoB,and LDL-C had area under the curve(AUC)values of 0.654(95％CI:0.641-0.667),0.608(95％CI:0.595-0.622),and 0.612(95％CI:0:592-0.633),respectively,as diagnostic indicators for metabolic syndrome in the study participants.Furthermore,Non-HDL-C demonstrated a significantly higher AUC compared to both ApoB and LDL-C(both P＜0.05).Conclusion The prevalence of MS is relatively high among adult Uygur residents in rural Xinjiang,and Non-HDL-C demonstrates a stronger correlation and predictive value for MS compared to ApoB and LDL-C.
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