首页|HIV感染者丙型肝炎病毒抗体与病毒载量关系

HIV感染者丙型肝炎病毒抗体与病毒载量关系

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目的 了解HIV感染者合并感染丙型肝炎病毒(HCV)后抗体与病毒载量(HCV RNA)之间的相关性,为HCV抗体评估HCV RNA的预测价值提供依据.方法 于2022年11月-2023年3月在云南省传染病医院收集确诊为HIV感染者血清和信息资料,采用酶联免疫吸附法检测HCV抗体,qRT-PCR法测定HCV RNA.采用t检验、x2检验等统计学方法进行数据分析.结果 收集到HIV感染者979例,HCV抗体检测阳性率为17.9％(176例),其中男性和女性分别为17.1％(110例)和19.6％(66例).HCV抗体阳性率与年龄有关(x2=107.662,P＜0.001),41～60岁感染者最高为29.6％(158例),而＜20岁感染者最低为0.在HCV抗体阳性感染者中进行HCV RNA检测阳性率为46.6％(82例),男性和女性阳性率分别为50％(55例)和40.9％(27例),经统计分析,HCV RNA阳性率与年龄无关(P＞0.05).Spearman等级分析显示,HCV RNA阳性与HCV抗体水平呈正相关(r=0.237,P＜0.05).采用ROC曲线对预测值进行分析,结果发现当HCV抗体值≥ 16.78(S/CO)时HCV RNA为阳性.结论 HIV感染者人群中HCV抗体阳性率较高,HCV抗体与HCV RNA水平之间呈正相关,HCV抗体对HCV RNA阳性预测的最佳临界值确定为16.78(S/CO),为HIV合并感染HCV患者诊断和治疗提供实验室依据.
Relationship between hepatitis C virus antibody and viral load in HIV-infected individuals:a hospital-based study in Yunnan province
Objective To understand the correlation between hepatitis C virus(HCV)antibodies and HCV RNA viral load in HIV co-infected individuals and to provide a basis for predicting HCV RNA based on HCV antibody detection.Methods The blood samples and relevant data were collected from 979 HIV-infected individuals with HCV antibody detection at the Yunnan Provincial Infectious Disease Hospital from November 2022 to March 2023.HCV antibodies were detected by enzyme-linked immunosorbent assay(ELISA),and HCV RNA was measured by real-time reverse transcription-PCR(qRT-PCR).T-test and chi-squared test were used for data analysis.Results Among all participants,17.9％(n=176)were HCV antibody positive,and the positive rates were 17.1％(n=110)and 19.6％(n=66)for male and female participants,respectively.The rate of HCV antibody positivity was associated with age(x2=107.662,P＜0.001),with the highest rate of 29.6％in participants aged 41-60 years and the lowest rate of 0％in participants younger than 20 years.Among participants who were HCV antibody positive,the HCV RNA positivity rate was 46.6％,with positive rates of 50.0％and 40.9％in male and female participants,respectively,and the positive rate was not related to age(P＞0.05).Spearman rank correlation analysis showed a positive correlation between HCV RNA positivity and HCV antibody levels(r=0.237,P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that an HCV antibody level ≥ 16.78(signal to cutoff ratio,S/CO)indicated HCV RNA positivity.Conclusion The rate of HCV antibody positivity was high in the HIV-infected population and positively correlated with HCV RNA levels,with an S/CO value of 16.78 being an optimal threshold for predicting HCV RNA positivity,which could be used in the diagnosis and management of patients co-infected with HIV and HCV.

HIV-infected individualshepatitis c virus antibodyhepatitis c viral load

亢丽娟、刘俊仪、朱燕涛、张米、张念、谢祺、刘仕芳、杨剑陶、李肖、何全英、王佳丽

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云南省传染病医院检验科,昆明 650301

大理大学公共卫生学院,大理 671003

昆明医科大学公共卫生学院,昆明 650224

HIV感染者 丙型肝炎病毒抗体 丙型肝炎病毒载量

国家自然科学基金云南省教育厅项目昆明医科大学艾滋病共感染传染性疾病诊疗科技创新团项目云南省高层次卫生技术人才培养经费资助项目云南省科技厅-昆明医科大学应用基础研究联合专项面上项目云南省科技厅-昆明医科大学应用基础研究联合专项面上项目

819606052019J1305CXTD202111H-2018050202101AY070001-223202201AY070001-208

2024

10.11847/zgggws1143319

中国公共卫生
中华预防医学会

中国公共卫生

CSTPCD北大核心
影响因子：1.404
ISSN：1001-0580
年,卷(期)：2024.40(7)