Absrtact:Objective To provide a scientific basis for early detection and intervention of human anthrax epidemic in Heilongjiang Province and the formulation of prevention and control measures.Methods Descriptive epidemiological analysis was conducted on the epidemic data of anthrax in Heilongjiang Province from 1979 to 2021.ArcGIS 10.8 and SaTScan 9.5 software were used to analyze the spatial autocorrelation and spatial-temporal aggregation of case data from 2004 to 2021.Results A total of 304 cases of anthrax were reported in Heilongjiang Province from 1979 to 2021,and the overall incidence showed an upward trend(x2=699,P<0.001);the incidence was mainly in the age group of>20-60 years old;the ratio of male to female was 3.83∶1;the occupation distribution was mainly farmers/herdsmen,accounting for 80.26%.The results of local autocorrelation analysis from 2004 to 2021 showed that there was obvious aggregation in the east and northeast.The results of spatio-temporal scanning analysis showed that it was most likely to gather in the eastern and northeastern regions with a radius of 107.61 km centered on Youyi county.Conclusion The incidence of anthrax in Heilongjiang Province showed an overall upward trend.The high incidence population was mainly male farmers/herdsmen aged>20-60 years old,and most of the gathering areas were located in the east and northeast of Heilongjiang Province.