Objective To dynamically analyze the effect of primary prevention health management in high-risk groups of cardiovascular diseases in Harbin City from 2020 to 2024,and to provide practical basis for the formation of active and accurate primary prevention strategies of cardiovascular diseases.Methods A total of 195 people ≥35 years old who were not at high risk of cardiovascular disease were selected as the study objects by simple random sampling,and were divided into high risk control group and high risk health management group(99 people and 96 people,respectively).The relevant indicators were dynamically monitored.Results Compared with the high-risk control group,systolic blood pressure,fasting blood glucose in 2021-2024,total cholesterol and serum low density lipoprotein cholesterol in 2022-2024 were significantly different in the high-risk health management group(P<0.05).From 2020 to 2024,systolic blood pressure(F=3.12),fasting blood glucose(F=3.56),total cholesterol(F=11.78),triglyceride(F=7.96)and serum low density lipoprotein cholesterol(F=14.23)of subjects in the high-risk health management group showed a decreasing trend.Serum high density lipoprotein cholesterol(F=3.98)was increased,and the differences were statistically significant(P<0.05).Conclusion The primary prevention and health management for the high-risk population of cardiovascular disease is effective and can effectively improve the level of related indicators.