Expression difference and analysis of serum CC16 in IPF and ILD associated with atmospheric fine particulate matter
Objective To investigate the expression difference of serum clara cell secretory protein(CC16)between idiopathic pulmonary fibrosis(IPF)and the interstitial lung disease(ILD)associated with long-term occupational exposure to atmospheric fine particulate matter,and to analyze the similarities and differences of alveolar-capillary barrier injury process.Methods The IPF patients diagnosed in the department of respiratory and critical care medicine of the First Affiliated Hospital of Harbin Medical University from November 2019 to May 2020 were collected as group A(n=20),ILD patients with long-term occupational exposure to atmospheric fine particulate matter as group B(n=18)and healthy volunteers as group C(n=18).The clinical data of the three groups were collected and the concentration of serum CC16 was detected by ELISA.One-factor analysis of variance was used to analyze the difference of serum CC16 levels among the three groups and the Tukey HSD test was used to analyze the difference of serum CC16 levels between each two groups.Results The concentration of serum CC16 in group A[(1318.15±96.93)pg/ml]was higher than that in group C[(1233.53±110.82)pg/ml],and the concentration of serum CC16 in group B[(1029.56±86.38)pg/ml]was lower than that in group C.The results of one-factor analysis of variance showed that the serum CC16 level was significantly different among group A,group B and group C(P＜0.05).The Tukey HSD test results showed that there were significant differences in serum CC16 levels between group A and group C,group B and group C,and group A and group B(P＜0.05).Conclusion There was significant difference in the concentration of serum CC16 between IPF and the ILD associated with long-term occupational exposure to atmospheric fine particulate matter.
Clara cell secretory proteinInterstitial lung diseaseIdiopathic pulmonary fibrosisAtmospheric fine particulate matterAlveolar-capillary barrier
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