重庆口岸输入性甲型H1N1流感病毒基因特征分析
Analysis of genetic characteristics of imported influenza A(H1N1)virus at Chongqing port
文海燕 1周岚 1彭彦卿 1倪丹妮 1叶盛 2刘高峰 3骆星丹1
作者信息
- 1. 重庆国际旅行卫生保健中心(重庆海关口岸门诊部),重庆 401147
- 2. 重庆市疾病预防控制中心;高致病性病原微生物重庆市重点实验室
- 3. 重庆海关
- 折叠
摘要
目的 了解重庆口岸输入性甲型H1N1流感病毒的基因特征,为重庆口岸流感防控提供参考.方法 使用高通量测序法对重庆口岸2023年1-6月检出的4株甲型H1N1流感病毒进行全基因组测序,使用生物信息学软件分析病毒株的全基因组特征.结果 重庆口岸2023年1-6月检出的4株甲型H1N1流感病毒株属于6B.1A.5a.2a和6B.1A.5a.2a.1进化分支,与世界卫生组织推荐的2023年北半球疫苗株相比,HA基因和NA基因序列无明显变化,抗原性和对神经氨酸酶敏感性也未发生明显改变.结论 4株病毒株未出现具有流行病学意义的变异,与疫苗株匹配性好.
Abstract
Objective To understand the genetic characteristics of imported influenza A(H1N1)virus at Chongqing port,and provide reference for influenza prevention and control at Chongqing port.Methods High throughput sequencing was used to sequence the whole genome of 4 strains of influenza A(H1N1)virus detected at Chongqing port from January to June 2023.The bioinformatics softwares were used to analyze the genomic characteristics of the virus strains.Results The 4 strains of influenza A(H1N1)virus detected at Chongqing port from January to June 2023 belonged to the evolutionary branches of 6B.1A.5a.2a and 6B.1A.5a.2a.Compared with the 2023 northern hemisphere vaccine strain recommended by World Health Organization,there was no significant change in the HA and NA gene sequences,and there was no significant change in antigenicity and sensitivity to neuraminidase.Conclusion The 4 virus strains did not show any epidemiological significant mutation and matched well with the vaccine strains.
关键词
甲型流感病毒/全基因组/进化特征Key words
Influenza A virus/Whole genome/Evolutionary characteristic引用本文复制引用
基金项目
重庆市技术创新与应用发展专项面上项目(CSTB2022TIAD-GPX0073)
海关总署科研项目(2022HK68)
出版年
2024
NETL
NSTL
万方数据