Analysis of genetic characteristics of imported influenza A(H1N1)virus at Chongqing port
Objective To understand the genetic characteristics of imported influenza A(H1N1)virus at Chongqing port,and provide reference for influenza prevention and control at Chongqing port.Methods High throughput sequencing was used to sequence the whole genome of 4 strains of influenza A(H1N1)virus detected at Chongqing port from January to June 2023.The bioinformatics softwares were used to analyze the genomic characteristics of the virus strains.Results The 4 strains of influenza A(H1N1)virus detected at Chongqing port from January to June 2023 belonged to the evolutionary branches of 6B.1A.5a.2a and 6B.1A.5a.2a.Compared with the 2023 northern hemisphere vaccine strain recommended by World Health Organization,there was no significant change in the HA and NA gene sequences,and there was no significant change in antigenicity and sensitivity to neuraminidase.Conclusion The 4 virus strains did not show any epidemiological significant mutation and matched well with the vaccine strains.
Influenza A virusWhole genomeEvolutionary characteristic
NETL
NSTL
万方数据
