Causal analysis of COVID-19 and herpes zoster:a Mendelian randomization study
Objective To evaluate the association between novel coronavirus pneumonia(COVID-19)and herpes zoster by using two sample Mendelian randomization,so as to explore whether COVID-19 is a factor causing herpes zoster.Methods All the data were collected from the public database of genome-wide association studies(GWAS).The secondary analysis of all the aggregated data was conducted,the genetic loci closely associated with COVID-19 were selected as instrumental variables(IVs).TSMR was conducted by seven methods,including Eggerregression in Mendelian randomization,weighted median,inverse variance weighted(IVW)random effects model,maximum likeli-hood,linear weighted median,IVW radial method and IVW fixed effects model,odds ratio(OR)value was used to e-valuate the causal relationship between COVID-19 and the risk of herpes zoster.Results Not more than 7 kinds of statistical methods of forward and reverse Mendelian randomization OR and 95％CI were 1.82(0.69-4.82)/0.98(0.95-1.01),1.23(0.90-1.67)/1.00(0.98-1.02),1.36(0.90-2.04)/1.00(0.98-1.03),1.23(0.90-1.67)/1.00(0.98-1.02),1.23(0.90-1.67)/1.00(0.98-1.02),1.03(0.61-1.75)/1.00(0.98-1.04),1.38(1.93-2.07)/1.00(0.96-1.04),all P values were greater than 0.05.The heterogeneity test results of TSMR P=0.39＞0.05,horizontal pleiotropy test P=0.43＞0.05.Conclusion There was no genetic evidence of correlation between COVID-19 and herpes zoster by using two-sam-ple Mendelian randomization.
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