Distribution and drug resistance analysis of carbapenem resistant Escherichia coli in a hospital from 2015 to 2022
Objective To analyze the distribution characteristics and drug resistance changes of carbapenem resistant Escherichia coli,and to provide basis for scientific prevention and control of hospital infections.Methods A retrospective study was used to analyze the distribution and drug sensitivity test of carbapenem resistant Escherichia coli isolated from clinical samples submitted to Jining First People's Hospital from January 2015 to December 2022.After the clinical samples(respiratory samples,blood,urine,secretions,sterile body fluids)were submitted for examination,single colonies were isolated by using fully automated bacterial identification and drug sensitivity tester for identification and drug sensitivity testing,carbapenem resistant Escherichia coli was identified.The distribution of departments and sample types were determined according to the sample information,the drug resistance rate of each antibiotic was determined according to drug sensitivity test.Results A total of 10 271 strains of Escherichia coli were detected from 2015 to 2022,including 196 strains(1.91％)of carbapenem resistant Escherichia coli.Among the detected patients,males(57.65％)were more than females(42.35％).Among the detection positive departments,the intensive care unit was the most one(41.33％).Among the samples distribution,urine samples were the most detected positive(49.49％).Carbapenem resistant Escherichia coli showed high rate of resistant to commonly used antibiotics.The drug resistance rate of β-lactam antibiotics(except for aztreonam)reached 100％,the resistance rate was lower(≤31％)of aminoglycoside antibiotic amikacin.Conclusion The positive rate of carbapenem resistant Escherichia coli in the hospital was high,and the bacteria were widely resistant to antibiotics.Therefore,antibiotics should be used reasonably to avoid hospital infection.
CarbapenemEscherichia coliNosocomial infectionGram negative bacilliDrug sensitivity test
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