Effect and efficacy of nebulized inhalation of Montelukast sodium combined with fluticasone propionate suspension on serum CRP,SAA and EOS levels in children with mycoplasma pneumonia
Objective To analyze the clinical efficacy of Montelukast sodium combined with fluticasone propionate aerosol inhalation in the treatment of mycoplasma pneumonia in children and the effects on the levels of serum C-reactive protein(CRP),amyloid A(SAA)and eosinophils(EOS),so as to provide guidance for the clinical treatment of mycoplasma pneumonia in children.Methods A total of 100 children with mycoplasma pneumonia treated in Dongying People's Hospital of Shandong Province from November 2021 to November 2023 were selected as the study objects,and were divided into study group(58 cases)and control group(42 cases)according to treatment methods.The control group was treated with Montelukast sodium,and the research group was treated with fluticasone propionate suspension atomized inhalation on the basis of the control group.Serum CRP,SAA,EOS levels,immune function,symptom resolution time,imaging changes and adverse reactions were compared between the two groups.Results After treatment,the levels of CRP(9.76±2.03)mg/L,SAA(4.60±1.15)mg/L,EOS[(0.42±0.06)×109/L]in the study group were lower than those in the control group(P＜0.05).After treatment,Th1/Th2(1.82±0.68),CD4+/CD8+(1.12±0.28)in the study group were higher than those in the control group(P＜0.05).In the study group,fever resolution time(321±0.75)d,cough resolution time(7.98±1.12)d,lesion absorption time(7.14±1.23)d,lung rales disappearance(7.35±1.43)d,total hospitalization time(8.75±1.23)d,was lower than that of control group(P＜0.05).After treatment,the detection rate of lung consolidation in the study group(1.72％)was lower than that in the control group(9.5％)(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Montelukast sodium combined with fluticasone propionate suspension aerosol inhalation could reduce inflammation,regulated the immune function,accelerated the resolution of clinical symptoms in children with mycoplasma pneumonia.
Montelukast sodiumFluticasone propionate suspensionMycoplasma pneumoniaInflammatory factorImmune function
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