Pathogen characteristics and risk factors analysis of acute cerebrovascular disease complicated with pulmonary infection
Objective To explore the distribution,drug resistance and risk factors of pathogenic bacteria in acute cerebrovascular disease complicated with pulmonary infection,in order to provide reference for clinical treatment.Methods A total of 105 patients with acute cerebrovascular disease complicated with pulmonary infection who were treated in our hospital from September 2019 to August 2022 were selected as the observation group,while 105 acute cerebrovascular disease patients without pulmonary infection were selected as the control group.The pulmonary infection pathogens and drug resistance were analyzed by automatic microbial detection,and the clinical data was compared to analyze the influencing factors of concurrent pulmonary infection.Results A total of 97 strains of pathogenic bacteria were detected from 105 patients of acute cerebrovascular disease complicated with pulmonary infection,mainly Gram-negative bacteria(55.67％),followed by Gram-positive bacteria(32.99％).The resistance of Pseudomonas aeruginosa to tobramycin and imipenem were low,7.32％and 17.07％,respectively.Klebsiella pneumoniae had low resistance to ciprofloxacin,gentamicin and imipenem,which were 10.81％,13.51％and 0.00％respectively.The resistance of Staphylococcus aureus to tolnenenebb furantoin,gentamicin and vancomycin was low,which were 0.00％,19.23％and 0.00％respectively.Staphylococcus epidermidis had low resistance to nitrofurantoin and vancomycin,which were 5.00％and 0.00％.respectively.The proportion of age,acute physiological function and chronic health status scoring system(APACHE Ⅱ),Glasgow coma(GCS)≤ 12,dysphagia,diabetes,mechanical ventilation history,and serum albumin＜35 g/L in the observation group were(66.43±7.78)years old,(17.82±2.05)points,36.19％,27.62％,41.90％,61.90％,and 69.52％,respectively,which were significantly higher than those in the control group(P＜0.05).Logistic regression analysis showed that age,APACHE Ⅱ score,GCS score,mechanical ventilation history,and serum albumin were influencing factors for pulmonary infection in patients with acute cerebrovascular disease(P＜0.05).Conclusion Acute cerebrovascular disease complicated with pulmonary infection was mainly Gram-negative bacteria,and the resistance rate of different pathogens to antibiotics was different.Acute cerebrovascular disease complicated with pulmonary infection was affected by the age of patients,APACHE Ⅱ score,GCS score,mechanical ventilation history and serum albumin level.
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