Analysis of pathogen characteristics and drug resistance in children with respiratory tract infection in a hospital from 2019 to 2021
Objective To analyze the characteristics of pathogenic bacteria and drug resistance in children with respiratory tract infection in a certain hospital,understand the situation of respiratory tract pathogen infection in the hospital,and provide scientific basis for clinical diagnosis and treatment.Methods A retrospective analysis of clinical data of 92 children with respiratory tract infections admitted to the Third People's Hospital of Bengbu City from 2019 to 2021 was conducted.According to the cases'age,all cases were divided into children group,toddler group and infant group.Indirect immunofluorescence assay was used for the detection of 9 kinds of respiratory tract pathogen,including influenza B virus(IFVB),Chlamydia pneumoniae(CPn),Coxiella burnetii,Mycoplasma pneumoniae,parainfluenza virus(PIVs),adenovirus(ADV),respiratory syncytial virus(RSV),Legionella pneumophila and influenza A virus(IFVA).Mycoplasma pneumoniae was isolated from childrens'sputum samples,the E-test method was used to test the drug resistance of the isolated strains to five antibiotics.Results Pathogens were detected positive in 57 cases out of 92 children with respiratory tract infection,including 17 cases of mixed infection with two or more pathogens,accounted for 18.48％,and 48 cases of single pathogen infection,accounted for 52.17％.The positive rates from 2019 to 2021 were 30.00％,34.48％,and 74.42％respectively,with the highest positive rate for Mycoplasma pneumoniae(27.17％).While,Chlamydia pneumoniae,Legionella pneumophila and Coxiella burnetii were all negative.The detection rate of Mycoplasma pneumoniae in 2021 was higher than that in 2019 and 2020(P＜0.05).The positive rate was highest in the children group,reached 68.97％.The drug resistance rates of Mycoplasma pneumoniae to tetracycline,ciprofloxacin,norfloxacin,erythromycin and azithromycin were 0.00％,4.00％,8.00％,12.00％and 16.00％respectively.Conclusion The main pathogen causing respiratory tract infections in children in the hospital from 2019 to 2021 was Mycoplasma pneumoniae.Mycoplasma pneumoniae exhibited certain resistance to antibiotics such as ciprofloxacin,norfloxacin,erythromycin and azithromycin.
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