Effect of STAT3 expression on the prognosis of children with congen-ital intestinal atresia complicated with abdominal infection
Objective To explore the prognostic effects of signal transducer and activator 3(STAT3)on children with congenital intestinal atresia complicated with abdominal infection,so as to provide a basis for its prevention and treatment.Methods A total of 106 infants with congenital intestinal atresia complicated by abdominal infection ad-mitted to Hebei Children's Hospital from January 2020 to January 2023 were enrolled.PCR method was used to determine the relative expression level of STAT3 mRNA in the affected intestinal tissues.According to the 6-month post operative treatment outcome,the patients were divided into survival group and death group,and the prognostic factors affecting infants with congenital intestinal atresia complicated by abdominal infection were screened.The rela-tionship between STAT3 expression and prognosis of infants with congenital intestinal atresia complicated by abdomi-nal infection was analyzed.Results Out of the 106 cases of infants with congenital intestinal atresia complicated by abdominal infection,68 cases survived,with a survival rate of 64.15％.The premature birth,low birth weight,Grosfeld pathology types Ⅲ-Ⅳ,postoperative short bowel syndrome,and the proportion of Th17 cells,IL-6 and STAT3 mRNA were higher in the death group than the survival group(P＜0.05),while TGF-β was lower than that of survival group(P＜0.05).Grosfeld pathology type(HR=2.672,95％CI:1.126-6.344),postoperative short bowel syndrome(HR=3.777,95％CI:1.115-12.794),Th17 cells(HR=4.899,95％CI:1.446-16.593),IL-6(HR=5.068,95％CI:1.496-17.167),and STAT3 mRNA(HR=6.092,95％CI:1.798-20.634)were identified as risk factors for mortality in infants with congenital intestinal atresia complicated by abdominal infection(P＜0.05)while TGF-β(HR=0.282,95％CI:0.083-0.954)was identi-fied as a protective factor(P＜0.05).The area under the curve(AUC)for predicting mortality in infants with congen-ital intestinal atresia complicated by abdominal infection using STAT3 mRNA was 0.904(0.845-0.964).There was a statistically significant difference in the survival curves among different groups based on STAT3 mRNA expression(P＜0.05).Conclusion Elevated expression of STAT3 mRNA is associated with poor prognosis in infants with congenital in-testinal obstruction complicated by intra-abdominal infection.
Congenital intestinal atresiaAbdominal infectionSignal transduction and transcriptional activator 3Survival prognosis
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