Effects of exercise prescription combined with vitamin D on body morphology,biochemical and imaging indexes in patients with nonalcoholic fatty liver disease
Objective To investigate the effects of exercise prescription and additional vitamin D supplementation on body morphology,biochemical and imaging indexes in patients with nonalcoholic fatty liver disease and its related mechanisms.Methods A total of 156 patients with nonalcoholic fatty liver disease treated at the Affiliated Hospital of Hebei Engineering University 2020-2022,were divided into control group,vitamin D group,exercise group,combi-nation group(exercise+vitamin D)according to Random-number Table method.They were given low-fat diet as pre-scribed by conventional doctors,and oral vitamin D supplement based on low-fat diet,respectively.On the basis of low-fat diet combined with exercise prescription,exercise prescription combined with oral vitamin D supplementation was implemented on the basis of low-fat diet.At the same time,individualized dietary intervention plans were formu-lated according to various factors such as living and eating habits,age,gender,body mass index and disease severity of different patients.After 3 months of strict implementation,the effect of the intervention was judged by imaging changes,physical changes,blood biochemical indexes and liver adipocytokines.Results The total effective rate of the control group was 87.17％,the vitamin D group was 89.74％,the exercise group was 94.87％,and the combined group was 97.43％.The total effective rate of the combined group was significantly higher than that of the other three groups,with statistical significance(t=11.703,P＜0.01).After intervention,body shape indexes were significantly lower than those before intervention,and the differences were statistically significant(t=3.238,P＜0.05).After intervention,the levels of total cholesterol,triglyceride and low density lipoprotein cholesterol in all the 4 groups were decreased,while high density lipoprotein cholesterol(HDL-C)was increased compared with that of before intervention,with statistical significance(t=6.489,P＜0.05).After intervention,the levels of TNF-α and NF-κB in vitamin D group and control group were decreased,while the levels of Irisin and ApN were increased,and the difference was statistically significant(t=20.134,P＜0.05).Conclusion Supplementation of vitamin D on the basis of diet and exercise inter-vention could further reduce the body shape and inflammatory factor levels in patients with nonalcoholic fatty liver disease,thereby improving liver lipid metabolism and phenotypic abnormalities.It is suggested that the mechanism might be related to the immunoregulate effect of vitamin D.
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