摘要
目的 分析境外输入新冠病毒的流行特征和基因组特征,为济南疫情防控工作提供参考依据.方法 收集济南航空口岸2022年6-12月境外输入新冠病毒感染者相关信息,分析其流行病学特征,筛选77例感染者样本使用二代测序技术进行高通量测序,分析基因分型及变异特征.结果 2022年6-12月,济南航空口岸累计报告输入性新冠病毒无症状感染者165例,男女性别比2.17∶1,平均年龄37.46岁;67.27％感染者接种过疫苗;职业以务工工人为主,占26.67％;来源国家主要是韩国,占21.21％.共获得77条有效的全基因组序列,按照Nextstrain分型法可分为8个型,均为Omicron变异株,优势进化分支主要是BA.2、BA.5.2及BA.5.10.1.系统发育分析表明,境外输入新冠病毒感染者的序列与来源国家的毒株序列高度同源.结论 济南航空口岸境外输入新冠病毒风险持续存在,在及时跟踪疫情动态的同时,变异监测及防控措施仍需坚持不懈.
Abstract
Objective To analyze the epidemical and genomic characteristics of abroad imported SARS-CoV-2,so as to provide scientific basis for the epidemic prevention and control at Jinan port.Methods The epidemiological characterization of information related to SARS-CoV-2 infections imported from abroad from June to December 2022 was collected from Jinan port.Seventy-seven infections'samples were screened for high-throughput sequencing using the second-generation sequencing technology analyzed for genotyping and variant features.Results A total of 165 cases of imported asymptomatic SARS-CoV-2 infection were reported at Jinan port,with a gender ratio of 2.17∶1,av-erage age 37.46 years old,67.27％of those infected had been vaccinated.Occupations were mainly migrant workers,accounted for 26.67％.The main source country was South Korea,accounted for 21.21％.The 77 effective whole genome sequences could be divided into 8 types according to Nextstrain typing,all of which were Omicron variants,and the dominant evolutionary branches were BA.2,BA.5.2 and BA.5.10.1.Phylogenetic tree analysis showed that the sequences of imported SARS-CoV-2 infections were highly homologous to those of the source countries.Conclusion The risk of overseas importation of SARS-CoV-2 at Jinan port will continue to exist.Mutation surveillance and pre-vention and control measures still need to be persevered while tracking the epidemic situation in a timely manner.
基金项目
山东省科技厅科学研究项目(2021CXGC011306)
济南海关科研项目(2023JK002)
济南海关科研项目(2023JK003)
NETL
NSTL
万方数据