Retinol-binding protein 4 and procalcitonin levels and predictive value for drug resistance in pulmonary tuberculosis patients
Objective To study the changes of retinol-binding protein-4(RBP4)and procalcitonin(PCT)levels,and the predictive value for drug resistance in patients with pulmonary tuberculosis,so as to provide reference for the di-agnosis and treatment of pulmonary tuberculosis.Methods The clinical data of 386 patients with tuberculosis ad-mitted to 301 Military Hospital Medical Center from January 2020 to December 2023 were retrospectively analyzed.After 2 months of treatment,the patients were divided into drug resistant group and non-drug resistant group accord-ing to the results of acid-fast bacillus culture in sputum and anti-tuberculosis drug susceptibility test.The levels of Vitamin A,RBP4 and PCT were compared between the two groups at admission.The independent risk factors of drug resistance in pulmonary tuberculosis patients were analyzed by multivariate Logistic regression,the predictive value of RBP4 and PCT on drug resistance in patients with pulmonary tuberculosis was analyzed by receiver operat-ing characteristic curve(ROC).Results There were 40 cases(10.36％)of 386 patients with pulmonary tuberculosis were drug resistant.The incidence of pulmonary cavity and PCT level in drug resistant group were higher than those in non-drug resistant group,the levels of vitamin A and RBP4 were lower than those in non-drug resistant group(P＜0.05).Logistic regression analysis showed that vitamin A and RBP4 increasing were the protective factors of pulmonary tuberculosis drug resistance(OR=0.331,0.258,P＜0.05),the pulmonary cavity and PCT increasing were the risk factors(OR=3.367,10.444,P＜0.05).ROC curve analysis showed that the AUC of RBP4 combined with PCT pre-diction was significantly higher than that of single prediction(P＜0.05).Conclusion Compared with non-drug resistant pulmonary tuberculosis patients,RBP4 level decreased and PCT level increased in drug resistant pulmonary tubercu-losis patients,and the combination of the two indexes could predict the drug resistance of tuberculosis.
Pulmonary tuberculosisRetinol-binding protein 4ProcalcitoninDrug resistanceForecast
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