Epidemiology of pks+Klebsiella pneumoniae and its association with colorectal cancer:research progress
Klebsiella pneumoniae is a Gram negative bacillus frequently responsible for hospital acquired infections.In recent years,its new pathogenic traits,attributed to the presence of the pks gene cluster,have garnered significant attention from the scientific community,particularly regarding its potential link to colorectal cancer.The pks gene island endows the strains with the ability to synthesize specific polyketide compounds,such as colibactin,which possess cytotoxic and genotoxic properties.These compounds can bind to host cell DNA,causing DNA damage,and possibly facilitating cancer development.Epidemiological studies indicate that the infection rate of pks+Klebsiella pneumoniae is rising annually and is widely distributed globally.Given its potential association with colorectal cancer,this article reviewed the epidemiological characteristics of pks+Klebsiella pneumoniae and its related research progress concerning colorectal cancer,aimed to provide insights for future research and clinical management.
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