首页|全国细菌耐药监测网2014-2021年血标本分离毗邻颗粒链菌的耐药性变迁

全国细菌耐药监测网2014-2021年血标本分离毗邻颗粒链菌的耐药性变迁

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目的 了解全国临床血标本分离毗邻颗粒链菌的耐药性变迁,为临床治疗提供依据。方法 按照全国细菌耐药监测网(CARSS)技术方案的要求开展细菌耐药监测工作,参考美国临床实验室标准化协会(CLSI)标准,分析2014-2021年CARSS成员单位血标本分离毗邻颗粒链菌对抗菌药物的敏感性数据。结果 2014-2021年CARSS成员单位每年血标本临床分离毗邻颗粒链菌为83~152株,2017年后呈逐渐增多趋势。血标本分离毗邻颗粒链菌对万古霉素敏感率为100%,对美罗培南的敏感率为93。7%,对头孢曲松、头孢噻肟、头孢吡肟的敏感率为90%左右,对左氧氟沙星的敏感率为82。8%,对青霉素的敏感率为65。0%,对红霉素和克林霉素的敏感率较低,分别为32。7%、46。8%。2014-2021年毗邻颗粒链菌对部分抗菌药物的敏感率有不同程度上升,对头孢吡肟、美罗培南的敏感率有所下降。结论 临床血标本毗邻颗粒链菌检出数量呈上升趋势,且对青霉素、头孢菌素、碳青霉烯类、氟喹诺酮类、大环内酯类均呈现不同程度耐药,但尚未发现对万古霉素耐药的菌株。
Change in antimicrobial resistance of Granulicatella adiacens isolated from blood specimens,CARSS,2014-2021
Objective To understand the change in antimicrobial resistance of Granulicatella adiacens(G.adia-cens)clinically isolated from blood specimens in China,provide basis for clinical treatment.Methods Surveillance on antimicrobial resistance of bacteria was carried out according to the requirements of China Antimicrobial Resis-tance Surveillance System(CARSS).Antimicrobial susceptibility testing results of G.adiacens isolated from blood specimens of member units of CARSS in 2014-2021 were analyzed based on standard of American Clinical and La-boratory Standards Institute(CLSI).Results 83-152 strains of G.adiacens were isolated from blood specimens from member units of CARSS each year from 2014 to 2021,there was a gradual increasing trend after 2017.The susceptibility rates of G.adiacens isolated from blood specimens to vancomycin and meropenem were 100%and 93.7%respectively,to ceftriaxone,cefotaxime and cefepime were about 90%,to levofloxacin,penicillin,erythromycin and clindamycin were 82.8%,65.0%,32.7%and 46.8%,respectively.From 2014 to 2021,susceptibility rates of G.adiacens to partial antimicrobial agents increased to varying degrees,but to cefepime and meropenem decreased.Conclusion The number of G.adiacens isolated from blood specimens showed a rising trend,G.adiacens exhibits varying degrees of resistance to penicillin,cephalosporins,carbapenems,fluoroquinolones and macrolides,but no vancomycin-resistant strain was found.

Granulicatella adiacensantimicrobial agentantimicrobial resistanceChina Antimicrobial Resis-tance Surveillance System

马慧敏、陈东科、曾晓艳、陈葳、孙立颖、郑波

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北京大学第一医院临床药理研究所,北京 100034

北京医院检验科,北京 100730

西安交通大学医学院第一附属医院检验科,陕西西安 710061

北京大学第一医院检验科,北京 100034

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毗邻颗粒链菌 抗菌药物 耐药性 全国细菌耐药监测网

中国药师协会资助项目

A202203

2024

中国感染控制杂志
中南大学

中国感染控制杂志

CSTPCD北大核心
影响因子:2.112
ISSN:1671-9638
年,卷(期):2024.23(4)
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