首页|CC及CXC趋化因子在流感病毒感染过程中调控不同免疫细胞的作用研究进展

CC及CXC趋化因子在流感病毒感染过程中调控不同免疫细胞的作用研究进展

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流行性感冒(简称流感)是由流感病毒感染引起的急性呼吸道传染病。流感病毒经呼吸道侵袭人体后,呼吸道上皮细胞首先作出反应,产生多种细胞因子诱导机体发挥免疫应答,其中CC趋化因子及CXC趋化因子在流感病毒感染过程中调控多种免疫细胞,在流感病毒感染早期控制炎症反应,维持机体稳态过程中发挥重要作用。分析宿主体内趋化因子调控免疫细胞在流感病毒感染过程中的作用机制,从而为治疗流感提供新的策略。本文主要针对流感病毒感染过程中发挥主要作用的CC趋化因子、CXC趋化因子及其相关受体对各类型免疫细胞的调节作用进行综述。
Research progress on the role of CC and CXC chemokines in regulating di-fferent immune cells during influenza virus infection
Influenza is an acute respiratory infectious disease caused by influenza virus infection.After influenza virus invades the human body through the respiratory tract,the epithelial cells of the respiratory tract react first and produce a variety of cytokines to induce immune responses of human body.CC chemokines and CXC chemokines regulate a variety of immune cells in the process of influenza virus infection,and play important roles in the control of inflammatory response and maintenance of homeostasis in human body at the early stage of influenza virus infec-tion.Analyzing the role of chemokines in regulating immune cells in host's body during the process of influenza vi-rus infection can provide new strategies for treating against influenza.In this paper,the regulatory effects on vari-ous types of immune cells by CC and CXC chemokines as well as their related receptors during influenza virus infec-tion are reviewed.

influenzaCC chemokineCXC chemokinechemokine receptorimmune cell

王文静、张善语、王晓龙

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山东中医药大学药学院,山东 济南 250355

教育部中医药经典理论重点实验室,山东 济南 250355

山东省中医药基础研究重点实验室,山东 济南 250355

山东中医药大学实验中心,山东 济南 250355

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流行性感冒 CC型趋化因子 CXC型趋化因子 趋化因子受体 免疫细胞

国家自然科学基金山东省自然科学基金

82003715ZR2021LZY017

2024

中国感染控制杂志
中南大学

中国感染控制杂志

CSTPCD北大核心
影响因子:2.112
ISSN:1671-9638
年,卷(期):2024.23(5)
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