Leukemia has become an important threat to human health,and infection complications are the main obstacle to the clinical leukemia treatment.The intestinal barrier integrity was damaged due to the tumor characte-ristics of leukemia and high-intensity chemotherapy,intestinal bacterial translocation is an important cause for bloodstream infection.Mucosal barrier injury laboratory-confirmed bloodstream infection(MBI-LCBI)is an impor-tant component of bloodstream infection in patients with acute leukemia,but relevant research is very limited.The paper reviews the mucosal barrier injury,bacterial translocation,as well as the definition,diagnosis and prevalence of MBI-LCBI,analyzes the mechanism of intestinal microecology in regulating intestinal mucosal barrier integrity and effect of MBI-LCBI,aiming to provide theoretical basis for prevention,treatment and management of chemo-therapy-induced mucositis and MBI-LCBI.
维普
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