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成人脓毒症肠道菌群失调及干预措施研究进展

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脓毒症在全球范围内发病率及病死率均很高,其治疗目前仍是一个世界性难题。越来越多的研究认为肠道菌群对脓毒症的发生、发展和演变均有影响。一方面脓毒症导致肠道菌群失调,诱发或加重终末器官功能障碍;另一方面肠道菌群的激活和有益微生物及其产物的减少可增加宿主对脓毒症的易感性。本文参考最新的文献和研究进展,旨在探讨成人脓毒症与肠道菌群的相互关系及发生肠道菌群失调的干预措施,以期为脓毒症的治疗开拓新的思路。
Research progress on disorder of intestinal microbiota and intervention measures in adult sepsis
With high morbidity and mortality,the treatment of sepsis still remains a worldwide problem.More and more studies believe that intestinal microbiota has an impact on the occurrence,development and evolution of sepsis.On one hand,sepsis leads to disorder of intestinal microbiota,inducing and aggravating terminal organ dys-function;on the other hand,the activation of intestinal microbiota as well as the reduction of beneficial microorga-nisms and their products can increase the host's susceptibility to sepsis.Refering to the latest literatures and research progress,this article aims to explore the relationship between adult sepsis and intestinal microbiota,as well as inter-vention measures for the disorder of intestinal microbiota,so as to develop new ideas for the treatment of sepsis.

sepsisdisorder of intestinal microbiotaintervention measure

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南京医科大学附属淮安第一医院急诊科,江苏 淮安 223300

脓毒症 肠道菌群失调 干预措施

2024

中国感染控制杂志
中南大学

中国感染控制杂志

CSTPCD北大核心
影响因子:2.112
ISSN:1671-9638
年,卷(期):2024.23(6)