Is COVID-19 a risk factor for infection/colonization with multidrug-re-sistant organisms?A survey on multidrug-resistant organisms infection in hospitalized patients during the COVID-19 pandemic
Objective To analyze whether coronavirus disease 2019(COVID-19)is a potential risk for the infec-tion/colonization with multidrug-resistant organisms(MDROs)in hospitalized patients during a surge admission of COVID-19 patients.Methods Data of hospitalized patients in a tertiary first-class hospital from December 1,2022 to January 31,2023 were retrospectively analyzed.Clinical data,antimicrobial therapy,and MDROs detection re-sult between COVID-19 patients and non-COVID-19 patients were compared.Patients with detected pathogens were divided into MDRO group and non-MDRO group.Risk factors for infection/colonization with MDROs in hos-pitalized patients were analyzed by multivariate logistic regression.Results A total of 16 710 patients were admitted in hospital,2 403 cases were in COVID-19 group,and 8.83％(113/1 280)were MDRO-infected cases;14 307 ca-ses were in non-COVID-19 group,and 4.43％(167/3 770)were MDRO-infected cases.The detection rate of car-bapenem-resistant Klebsiella pneumoniae(CRKP)in patients in COVID-19 group was higher than that in non-CO-VID-19 group(48.15％vs 30.89％,P=0.028).Multivariate analysis results showed that critical illness(OR=4.796,95％CI:3.524-6.527),antimicrobial therapy≥2days before pathogen culture(OR=2.330,95％CI:1.699-3.196),positive fungi culture(OR=1.780,95％CI:1.318-2.405),long hospital stay(OR=1.036,95％CI:1.030-1.042)were risk factors for MDRO infection/colonization in hospitalized patients(all P＜0.05).Conclusion During mass admission of COVID-19 patients,MDROs infection/colonization is related to critical ill-ness,antimicrobial use,positive fungi culture and long hospital stay,while COVID-19 infection is not a risk factor for MDROs infection/colonization.
万方数据
维普
