目的 采用荟萃分析的方法，系统评价中国医疗机构开展主动筛查对耐碳青霉烯类肠杆菌目细菌(CRE)医院感染的防控效果。方法 计算机检索万方数据库、维普医学网、中国知网、中国生物医学文献数据库、Embase、PubMed、Cochrane Library、Web of Science 8个数据库自建库至2024年4月发表的关于中国医疗机构CRE主动筛查联合干预的研究，采用Meta分析研究主动筛查联合干预对CRE的防控效果。结果 共纳入文献14篇，含12篇非随机对照研究，2篇随机对照研究。Meta分析结果显示，开展住院患者CRE主动筛查并及时采取干预措施可有效降低CRE医院感染发病率[相对危险度(RR)=0。51，95％CI(0。43，0。61)，P＜0。05]。结论 开展住院患者的CRE主动筛查联合干预能有效降低CRE医院内交叉感染的风险。
Effectiveness of active screening combined with intervention in CRE pre-vention and control in medical institutions:a Meta-analysis
Objective To systematically evaluate the effectiveness of active screening in the prevention and control of healthcare-associated infection(HAI)with carbapenem-resistant Enterobacterales(CRE)in Chinese medical in-stitutions through Meta-analysis.Methods Studies on active screening combined with intervention for CRE in Chi-nese medical institutions published from the establishment of databases to April 2024 were retrieved from Wanfang Database,VIP database,China National Knowledge Infrastructure,China Biomedical Literature Database,Em-base,PubMed,Cochrane Library,and Web of Science.Meta-analysis was performed to study the effectiveness of active screening combined with intervention in CRE prevention and control.Results A total of 14 literatures were included in the analysis,including 12 non-randomized controlled studies and 2 randomized controlled studies.Meta-analysis results showed that active screening and timely intervention measures against CRE in hospitalized patients could effectively reduce the incidence of HAI with CRE(relative risk[RR]=0.51,95％CI[0.43,0.61],P＜0.05).Conclusion Active screening combined with intervention for CRE among hospitalized patients can effectively reduce the risk of CRE cross infection in hospitals.
万方数据
维普
