Experimental study on effect of intermittent administration frequency on microorganisms at the surface of needleless connectors for infusion
Objective To provide theoretical basis for determining whether disinfection is necessary before reco-nnecting the infusion device after intermittent administration of medicine via needleless connectors(NC)during in-travenous infusion.Methods The actual situation of clinical intravenous infusion was simulated in a laboratory en-vironment.Taking intravenous injection as an example,microorganisms on the surface of NC and in the remaining liquid after infusion at different intermittent administration times(1-9 times)were detected by adenosine triphos-phate(ATP)bioluminescence detection technique.The experiment was repeated in 15 groups for each administra-tion frequency,and a total of 270 specimens were detected and statistically analyzed.ATP detection value ≤25 rela-tive light unit(RLU)was considered to be qualified.Results With the increase of intermittent administration fre-quency,the overall microorganisms on NC surface gradually increased,but all were ≤25 RLU.Microorganisms on the surface of NC among different disconnection times were statistically different(P＜0.001).Compared with the microorganisms when disconnecting 9 times,numbers of microorganisms on the surface of NC with disconnection of 1,2,3,and 4 times were all statistically different,respectively(all P＜0.05),while those with other disconnec-tion frequencies did not show statistical differences among each other(all P＞0.05).Microorganisms in liquid after infusion among different intermittent administration frequencies were not statistically different(P=0.946).Conclusion In laboratory environment,with the increase of intermittent administration frequency,microorganisms on the sur-face of NC increase,but the safety of the infusion process is not compromised.
万方数据
维普
