Objective To provide theoretical basis for determining whether disinfection is necessary before reco-nnecting the infusion device after intermittent administration of medicine via needleless connectors(NC)during in-travenous infusion.Methods The actual situation of clinical intravenous infusion was simulated in a laboratory en-vironment.Taking intravenous injection as an example,microorganisms on the surface of NC and in the remaining liquid after infusion at different intermittent administration times(1-9 times)were detected by adenosine triphos-phate(ATP)bioluminescence detection technique.The experiment was repeated in 15 groups for each administra-tion frequency,and a total of 270 specimens were detected and statistically analyzed.ATP detection value ≤25 rela-tive light unit(RLU)was considered to be qualified.Results With the increase of intermittent administration fre-quency,the overall microorganisms on NC surface gradually increased,but all were ≤25 RLU.Microorganisms on the surface of NC among different disconnection times were statistically different(P＜0.001).Compared with the microorganisms when disconnecting 9 times,numbers of microorganisms on the surface of NC with disconnection of 1,2,3,and 4 times were all statistically different,respectively(all P＜0.05),while those with other disconnec-tion frequencies did not show statistical differences among each other(all P＞0.05).Microorganisms in liquid after infusion among different intermittent administration frequencies were not statistically different(P=0.946).Conclusion In laboratory environment,with the increase of intermittent administration frequency,microorganisms on the sur-face of NC increase,but the safety of the infusion process is not compromised.
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