脂肪性肝病的诊断和评估
Diagnosis and evaluation of fatty liver disease
蒋婷婷 1邓雯 1王诗雨 1杨柳 1毕潇月 1林妍洁 2路遥 1易为 3李明慧 4谢尧4
作者信息
- 1. 首都医科大学附属北京地坛医院 肝病二科,北京 100015
- 2. 北京大学地坛医院教学医院 肝病二科,北京 100015
- 3. 首都医科大学附属北京地坛医院 妇产科,北京 100015
- 4. 首都医科大学附属北京地坛医院 肝病二科,北京 100015;北京大学地坛医院教学医院 肝病二科,北京 100015
- 折叠
摘要
近年来,随着肥胖和代谢综合征的流行,脂肪性肝病的发病率呈上升趋势,已取代慢性病毒性肝炎成为我国最常见的慢性肝脏疾病.脂肪性肝病与肝硬化、肝细胞癌的发生密切相关,早期诊断并尽早干预有利于减轻疾病负担,控制疾病进展.肝穿刺活检是诊断脂肪性肝病的"金标准",但因有创、评价不一致和显著并发症等局限性限制其广泛应用.目前临床迫切需要无创方法诊断脂肪性肝病,也需要无创标志物筛查、监测患者病情变化和判断疗效.本文从脂肪性肝病的定义、疾病谱、有创诊断、无创诊断几方面进行综述,以期为脂肪性肝病的诊疗工作提供帮助.
Abstract
In recent years,with the prevalence of obesity and metabolic syndrome,the incidence of fatty liver disease is on the rise,and it has been replaced chronic viral hepatitis as the most common chronic liver disease in China.Fatty liver disease is closely related to the occurrence of cirrhosis and hepatocellular carcinoma.Therefore,early diagnosis and intervention are beneficial to reduce the burden of disease and control the progression of the disease.Liver biopsy is the"gold standard"for the diagnosis of fatty liver disease,however,its wide application is limited by invasiveness,inconsistent evaluation and significant complications.At present,there is an urgent need for non-invasive methods to diagnose fatty liver disease,as well as non-invasive marker screening,monitoring patients'disease changes and judging the curative effect.This paper reviewed the definition,disease spectrum,invasive diagnosis and non-invasive diagnosis of fatty liver disease,in order to provide help for the diagnosis and treatment of fatty liver disease.
关键词
脂肪性肝病/有创诊断/无创诊断/评估Key words
Fatty liver disease/Invasive diagnose/Non-invasive diagnose/Evaluation引用本文复制引用
基金项目
国家重点研发计划(2022YFC2603500)
国家重点研发计划(2022YFC2603505)
北京市医院管理中心临床医学发展专项经费资助(XMLX202127)
首都卫生发展专项公共卫生项目(首发2022-1-2172)
北京市医院管理中心消化内科学科协同发展中心资助课题(XXZ0302)
出版年
2024
NETL
NSTL
万方数据